2.3.5 Transporter Proteins

Solute carrier (SLC) and ATP-binding cassette (ABC) transporters move ions and small molecules across...

Solute carrier (SLC) and ATP-binding cassette (ABC) transporters move ions and small molecules across membranes. Selective serotonin reuptake inhibitors (SSRIs) act by blocking the serotonin transporter (SERT); SGLT2 inhibitors such as canagliflozin block renal glucose reabsorption; and P-glycoprotein (MDR1), an ABC transporter, is central to multidrug resistance in cancer chemotherapy.