2.3.4 Nuclear Receptors

Nuclear receptors are ligand-activated transcription factors that, upon binding a lipophilic ligand, translocate to the nucleus and regulate gene expression...

Nuclear receptors are ligand-activated transcription factors that, upon binding a lipophilic ligand, translocate to the nucleus and regulate gene expression directly. Glucocorticoid, thyroid hormone, retinoic acid, and PPAR receptors (targeted by glitazone antidiabetic drugs) belong to this family, and their pharmacology is characterised by relatively slow onset but long duration of action, reflecting the time required for transcriptional and translational responses.