2.3 Druggable Target Classes
2.3 Druggable Target Classes contains 8 topic pages in Phase 2 — Target Identification & Compound Profiling.
Topic Group
Topics
Continue through the related topic pages.
2.3.1 G-Protein-Coupled Receptors (GPCRs)
GPCRs constitute the largest single class of drug targets in current...
2.3.2 Ion Channels
Ion channels may be ligand-gated (for example GABA-A or nicotinic acetylcholine receptors) or voltage-gated (sodium, potassium, or calcium...
2.3.3 Enzymes
Enzymes are catalytic proteins that can be inhibited to block a specific biochemical...
2.3.4 Nuclear Receptors
Nuclear receptors are ligand-activated transcription factors that, upon binding a lipophilic ligand, translocate to the nucleus and regulate gene expression...
2.3.5 Transporter Proteins
Solute carrier (SLC) and ATP-binding cassette (ABC) transporters move ions and small molecules across...
2.3.6 Kinases
Kinases catalyse phosphorylation-based signal transduction and represent a major class of contemporary anticancer...
2.3.7 DNA and RNA
Nucleic acids themselves may be direct drug targets, particularly in oncology.
2.3.8 Structural Proteins
Cytoskeletal and cell-wall structural proteins are also druggable.